Ajax opened their UEFA Champions League 2025 league-stage campaign with a 2–0 defeat at home to Inter on Wednesday, 17 September 2025. The match at the Johan Cruyff Arena kicked off at 19:00 UTC with English referee Michael Oliver in charge. Inter held a 1–0 lead at half-time and added a second goal after the break to secure a dominant away victory on Matchday 1.

For Ajax, this loss was a heavy blow to their ambitions of progressing from the league phase. A home defeat in the op...