Napoli opened their Serie A 2025 campaign with a commanding 2–0 victory over Sassuolo on Saturday, 23 August 2025, at the Mapei Stadium. The match, which kicked off at 16:30 UTC, was officiated by referee Giovanni Ayroldi of Italy. Napoli went into the break with a 1–0 lead and added a second goal in the second half to seal all three points on Matchday 1.

For Napoli, this result was a statement of intent at the very start of the season. A clean-sheet win away from home, against ...