Genoa opened their home campaign at the Stadio Luigi Ferraris on Sunday, 31 August 2025, falling to a 1–0 defeat against Juventus on Serie A Matchday 2. Daniele Chiffi of Italy officiated the 16:30 UTC kickoff, and the two sides went into the break level at 0–0. The single goal after the interval was enough to separate the teams, handing Juventus maximum points on the road and leaving Genoa with work to do in front of their own supporters.

For Genoa, this defeat on the second matchday o...