Santa Clara opened their 2025 Primeira Liga campaign with a 0–1 defeat at home to Moreirense on Sunday, 17 August 2025, in a Matchday 2 fixture that kicked off at 17:00 UTC. Referee David Rafael Oliveira da Silva of Portugal oversaw the contest, which saw the visitors take a 1–0 lead into the half-time interval. The result at the Estádio de São Miguel handed Moreirense their first three points of the season while leaving Santa Clara still searching for their maiden victory.

For Santa Clara, the...