St. Louis City fell to a 1–2 defeat against San Diego at home on Sunday, 11 May 2025, in a Major League Soccer Matchday 12 fixture that kicked off at 00:30 UTC. Referee Allen Chapman oversaw the contest, which entered the break with a 0–0 scoreline before both sides found the net in the second half. The result handed San Diego three valuable points on the road while leaving St. Louis City to rue a missed opportunity in front of their own supporters.

For St. Louis City, the loss at home on M...