Tigres UANL fell to a 1–3 defeat against Club America on Sunday, 17 August 2025, at the Estadio Universitario in a Liga MX Matchday 5 clash. The match kicked off at 01:00 UTC under the supervision of referee César Ramos Palazuelos of Mexico. The teams went into the break level at 1–1, but Club America pulled clear in the second half to claim all three points in this early-season edition of the Clásico Nacional.

For Tigres UANL, the loss at home represented a significant setback in their pursuit...