Mazatlán opened their Liga MX 2025 campaign with a 2–1 victory over Puebla on Saturday, 19 July 2025, at a kickoff time of 03:05 UTC. The match, officiated by referee Katia García of Mexico, was the second fixture of the regular season for both sides. Mazatlán held a 2–0 lead at half-time, a margin that proved decisive as they secured all three points at the final whistle.

For Mazatlán, this result marked a strong start to their season. After a single matchday, two points from a win placed them...