Bayer Leverkusen began their Bundesliga 2025 title defence with a 1–2 defeat at home to 1899 Hoffenheim on Saturday, 23 August 2025. The Matchday 1 fixture, refereed by Daniel Siebert, kicked off at 13:30 UTC and saw the teams go into the break level at 1–1. The result handed Hoffenheim an early statement win at the BayArena, while Leverkusen dropped points on the opening weekend of the new campaign.

For 1899 Hoffenheim, the victory represented a powerful start to the season, immediatel...